Development of a highly selective fluorescence probe for hydrogen sulfide |
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| Authors: | Sasakura Kiyoshi Hanaoka Kenjiro Shibuya Norihiro Mikami Yoshinori Kimura Yuka Komatsu Toru Ueno Tasuku Terai Takuya Kimura Hideo Nagano Tetsuo |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | ![]()
Hydrogen sulfide (H(2)S) has recently been identified as a biological response modifier. Here, we report the design and synthesis of a novel fluorescence probe for H(2)S, HSip-1, utilizing azamacrocyclic copper(II) ion complex chemistry to control the fluorescence. HSip-1 showed high selectivity and high sensitivity for H(2)S, and its potential for biological applications was confirmed by employing it for fluorescence imaging of H(2)S in live cells. |
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