A novel type of matrix for surface-assisted laser desorption–ionization mass spectrometric detection of biomolecules using metal-organic frameworks |
| |
| Authors: | Chien-Ping Fu Stephen LirioWan-Ling Liu Chia-Her Lin Hsi-Ya Huang |
| |
| Institution: | Department of Chemistry, Chung Yuan Christian University, Chung Li District, Taoyuan City, 320, Taiwan |
| |
| Abstract: | A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules. |
| |
| Keywords: | Metal-organic frameworks Biomolecules Carbohydrates Peptides Surface-assisted laser desorption&ndash ionization mass spectrometry |
| 本文献已被 ScienceDirect 等数据库收录！ |
