IBX-mediated alpha-hydroxylation of alpha-alkynyl carbonyl systems. A convenient method for the synthesis of tertiary alcohols |
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| Authors: | Kirsch Stefan F |
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| Affiliation: | Department Chemie, Technische Universit?t München, Lichtenbergstr. 4, D-85747 Garching, Germany. stefan.kirsch@ch.tum.de |
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| Abstract: | ![]()
[reaction: see text] IBX (o-iodoxybenzoic acid) is an excellent reagent for the alpha-hydroxylation of alpha-alkynyl carbonyl compounds without giving dehydrogenation products. The convenient procedure proves to be useful for the construction of a variety of tertiary alcohols (55-91%) under mildly acidic conditions. |
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