| 3-间硝基苯基/对硝基苯基-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成 |
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| 引用本文： | 史海健,史好新,王忠义.3-间硝基苯基/对硝基苯基-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成[J].有机化学,1999(2). |
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| 作者姓名： | 史海健 史好新 王忠义 |
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| 作者单位： | 安徽师范大学化学系 芜湖241000
(史海健，史好新)，中国科技大学化学系 合肥230026(王忠义) |
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| 基金项目： | 安徽省自然科学基金，安徽省教委基金 |
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| 摘 要： | 报道了以3-间硝基苯基/对硝基苯基-4-氨基-5-巯基-1,2,4-三唑与芳酸在磷酰氯的作用下,合成了16个标题化合物,并研究了合成反应的条件。观察了部分标题化合物对金黄色葡萄球菌和大肠杆菌有明显的抑菌作用。
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| 关 键 词： | 3-芳基-4-氨基-5-巯基-1 2 4-三唑 3 6-二芳基-1 2 4-三唑并[3 4-b]-1 3 4-噻二唑 合成 生物活性 |
Studies on Synthesis of 6-aryl-3-(3-nitrophenyI/4-nitro-phenyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazole Derivatives |
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| SHI Hai - Jian,SHI Hao - Xin.Studies on Synthesis of 6-aryl-3-(3-nitrophenyI/4-nitro-phenyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazole Derivatives[J].Chinese Journal of Organic Chemistry,1999(2). |
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| Authors: | SHI Hai - Jian SHI Hao - Xin |
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| Abstract: | Sixteen title compounds have been prepared by the reaction of 4 - amino - 5 - mercapto - 3 - ( 3 - nitrophenyl/4 - nitrophenyl) - 1,2,4- triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride. The synthetic reaction conditions has been investigated. All the compounds were screened for antimicrobial activity against bacteria Staphylococcus aureus and Escherichia coli. Some compounds appeared very strong antibacterial activity. |
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| Keywords: | 4 - amino - 3 - aryl - 5 - mercapto - 1 2 4- triazole 3 6- diaryl - 1 2 4 - triazolo [3 4-b] - 1 3 4- thiadiazoles synthesis biological activity |
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