Study on the Supramolecular Inclusion Complex of β-Cyclodextrin with Retinoic Acid

The importance of Vitamin A for human health has been stressed in resent studies, meanwhile its derivative so-called retinoic acid (RA) has been widely used as pharmaceutical to treat several types of skin disease and cancer. However the application of retinioc acid is restrained for its poor water solubility, unstability and side affect on the human body. A large number of studies in pharmaceutical field showed that β-CD could inqjrove the water solubility of poorly soluble of drugs, reduce the toxicity and increase the dissolution rate, In the present work, the inclusion compound of retinoic acid with β-cyclodextrin was prepared by coprecipitating method, the structure of resulting product was studied by elemental analysis, differental scanning caloriemetry(DSC) analysis, FT-IR spectroscopy and X-ray diffractometry, and the formed supramolecule self-assembles in aqueous solution according to molar ratio 2:1 of host-guest.