The Syntheses of Novel 7-Methyl-3-Substituted-1,2,4-Triazolo[3,4-b] benzothiazoles

Tricyclazole is one of the benzothiazole derivatives, which are well known for developing this synthesis as many compounds with this ring system are associated with diverse biological activities such as application as potent antibacterials^1,2] and as fungicides for the control of Piricularia oryzae in the prevention of rice blast^3]. In particular, s-triazolo3,4-b]benzothiazole derivatives are of interest because of their broad spectra of biological activities. Therefore, it was planned to investigate a system, which combines these three biologic components in a molecule to give a compact system for screening their biologic activities. Recently, we have synthesized a novel 7-methyl-3-substituted-1,2,4-triazolo3,4-b]benzothiazole from p-methylaniline to 5 with various aromatic carboxylic acids in the presence of phosphorus oxychloride. The structures of these compounds were established by elemental analysis, NMR, MS and IR techniques.