A facile synthesis of the basic steroidal skeleton using a Pauson-Khand reaction as a key step |
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| Authors: | Kim Do Han Kim Kwang Chung Young Keun |
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| Affiliation: | Intelligent Textile System Research Center and Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea. |
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| Abstract: | A high-yield synthesis of steroid-type molecules under mild reaction conditions is achieved in two steps involving nucleophilic addition of alkynyl cerium reagent to an easily enolizable carbonyl compound (beta-tetralone) followed by an intramolecular Pauson-Khand reaction. |
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