Numerical simulation on the adaptation of forms in trabecular bone to mechanical disuse and basic multi-cellular unit activation threshold at menopause |
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Authors: | He Gong Yubo Fan Ming Zhang |
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Institution: | (1) Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China;(2) Department of Bioengineering, Beihang University, Beijing, 100083, China;(3) Department of Mechanics, Jilin University, Changchun, 130012, China |
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Abstract: | The objective of this paper is to identify the effects of mechanical disuse and basic multi-cellular unit (BMU) activation
threshold on the form of trabecular bone during menopause. A bone adaptation model with mechanical- biological factors at
BMU level was integrated with finite element analysis to simulate the changes of trabecular bone structure during menopause.
Mechanical disuse and changes in the BMU activation threshold were applied to the model for the period from 4 years before
to 4 years after menopause. The changes in bone volume fraction, trabecular thickness and fractal dimension of the trabecular
structures were used to quantify the changes of trabecular bone in three different cases associated with mechanical disuse
and BMU activation threshold. It was found that the changes in the simulated bone volume fraction were highly correlated and
consistent with clinical data, and that the trabecular thickness reduced significantly during menopause and was highly linearly
correlated with the bone volume fraction, and that the change trend of fractal dimension of the simulated trabecular structure
was in correspondence with clinical observations. The numerical simulation in this paper may help to better understand the
relationship between the bone morphology and the mechanical, as well as biological environment; and can provide a quantitative
computational model and methodology for the numerical simulation of the bone structural morphological changes caused by the
mechanical environment, and/or the biological environment.
The project supported by The Hong Kong Polytechnic University Research Grants (1-BB81 and G-YX64) and the National Natural
Science Foundation of China (10502021 and 10529202). |
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Keywords: | Disuse Activation Trabecular bone Menopause Functional adaptation |
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