川崎病患儿血铅水平与冠状动脉损伤

为探讨铅在川崎病冠状动脉损伤中的作用，对36例川崎病患儿在起病2～4周行超声心动图检查，分为冠状动脉损伤组（25例）和无冠状动脉损伤组（11例），以健康儿童作为正常对照组（15例），采用钨舟原子化法检测全血铅水平。结果表明，冠状动脉损伤组和无冠状动脉损伤组川崎病患儿血铅分别为（63．66±26．47）μg／L和（40．64±12．52）μg／L，均高于正常对照组的（20．88±13．32）μg／L（P〈0．05），且冠状动脉损伤组血铅又高于无冠状动脉损伤组（P〈0．05）。提示铅在川崎病的发病及其冠状动脉损伤中起重要作用，川崎病患儿应及时检查铅含量，即使未达中毒剂量也应驱铅治疗。

The Blood Lead Level of Children with Kawasaki Disease and Coronary Artery Lesion

To detect the blood lead level of children with Kawasaki disease and investigate the role of leadon the pathogenesis of coronary artery lesion, 36 patients with Kawasaki disease were divided into coronary artery lesion group （25 cases） and non - coronary artery lesion group （11 cases） according to eehocardiogram in 2 ～4 weeks after the onset. The content of lead in whole blood in children with Kawasaki disease and 17 healthy children was investigated by Wu Zhou atomization method. The result showed that the lead level of patients with Kawasaki disease with coronary artery lesion group and non - coronary artery lesion group were （63.66 ±26.47 ） μg/L and （40.64 ± 12.52） μg/L respectively. Both was obviously higher than that of the control group whose level was （20. 88 ±13.32） μg/L （P 〈 O. 05 ）. The lead level of patients with Kawasaki disease with coronary artery lesion group was higher than that of non coronary artery lesion group（P 〈 0.05）. It concludes the lead participates in pathogenesis of Kawasaki disease and the coronary artery damage. It is suggested that the content of lead in children with Kawasaki disease should be checked and they should be treated even if their blood lead level were not be toxic dose.