Bisphosphonate prodrugs: synthesis of new aromatic and aliphatic 1-hydroxy-1,1-bisphosphonate partial esters |
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| Authors: | Maelle Monteil Evelyne Migianu Marc Lecouvey |
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| Institution: | a Laboratoire de Chimie Structurale Biomoléculaire BIOMOCETI (UMR 7033-CNRS), UFR S.M.B.H. Université Paris 13. 74, Rue Marcel Cachin, F-93017 Bobigny Cedex, France
b Laboratoire de Biochimie des Protéines et Protéomique EA 3408, UFR S.M.B.H. Université Paris 13. 74, Rue Marcel Cachin, F-93017 Bobigny Cedex, France |
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| Abstract: | Methods for the preparation of various 1-hydroxy-1,1-bisphosphonate partial esters were developed. They were obtained from (alkyl or phenyl) bis(trimethylsilyl) phosphite and aromatic or aliphatic acid chlorides, followed by methanolysis. |
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| Keywords: | Bisphosphonate Arbusov reaction |
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