The microbiological transformation of steroidal saponins by Curvularia lunata |
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Authors: | Bing Feng Li-ping Kang |
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Institution: | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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Abstract: | The microbiological transformation of polyphyllin I (compound I), polyphyllin III (compound II), polyphyllin V (compound III) and polyphyllin VI (compound IV) by Curvularia lunata into their corresponding subsaponins, for example, diosgenin-3-O-α-l-arabinofuranosyl (1→4)-β-d-glucopyranoside (compound V), diosgenin-3-O-α-l-rhamnopyranosyl (1→4)-β-d-glucopyranoside (compound VI), diosgenin-3-O-β-d-glucopyranoside (compound VII) and pennogenin-3-O-β-d-glucopyranoside (compound VIII), were studied in this paper. Curvularia lunata is able to hydrolyze terminal rhamnosyls that are linked by 1→2 C- bond to sugar residues of steroidal saponins at C-3 position with high activity and regioselectivity. |
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Keywords: | Biotransformation Curvularia lunata Polyphyllin I Polyphyllin III Polyphyllin V Polyphyllin VI |
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