Use of tetrahydropyrimidinium salts for highly efficient palladium-catalyzed cross-coupling reactions of aryl bromides and chlorides |
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Authors: | Ismail Özdemir Serpil Demir |
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Institution: | a Department of Chemistry, Inönü Universityt, 44280 Malatya, Turkey b Department of Chemistry, Ege University, 35100 Bornova-Izmir, Turkey |
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Abstract: | New, sterically demanding 1,3-dialkyl-3,4,5,6-tetrahydropyrimidinium salts (2) as NHC precursors have been synthesized and characterized. These salts, in combination with palladium acetate, provided active catalysts for the cross-coupling of aryl chlorides and bromides under mild conditions. The catalytic system was applied to the Heck, Suzuki and benzaldehyde (Kumada) coupling reactions. Catalyst activity was found to be influenced by the presence of a methoxy group on the ring of the p-position of benzyl substituent of the ligand precursor. |
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Keywords: | N-Heterocyclic carbene Suzuki coupling |
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