Mn(III)-based C-C bond formation: regioselective α′-allylation of various α,β-unsaturated, α and β-alkoxy α,β-unsaturated ketones |
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Authors: | Cihangir Tanyeli Devrim Özdemirhan |
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Institution: | a Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey b Department of Chemistry, Abant ?zzet Baysal University, 14280 Bolu, Turkey |
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Abstract: | The Manganese(III)-based regioselective α′-keto radical generation of unsaturated ketones is a versatile synthetic procedure with broad applicability. The generated α′-keto radical slowly creates a metal enolate in a solvent at reflux. The resultant metal enolate affords the corresponding α′-allylated α,β-unsaturated ketones in good yields. This method is the first example of the metal mediated regioselective α′-allylation of α,β-unsaturated ketones. The ketones that have α or β-alkoxy groups also work efficiently. |
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Keywords: | Enones Manganese and compounds Allylation |
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