Synthesis of functionalized α-amino-phosphine oxides and -phosphonates by addition of amines and aminoesters to 4-phosphinyl- and 4-phosphonyl-1,2-diaza-1,3-butadienes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of functionalized α-amino-phosphine oxides and -phosphonates by addition of amines and aminoesters to 4-phosphinyl- and 4-phosphonyl-1,2-diaza-1,3-butadienes

Authors:	Francisco Palacios^{,Domitila Aparicio,Yago Ló} pez,Jesú s M. de los Santos

Affiliation:	Departamento de Química Orgánica I, Facultad de Farmacia. Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain

Abstract:	1,2-Diaza-1,3-butadienes derived from phosphine oxides and phosphonates and with optically active substituents on N-1 and C-3 are obtained by 1,4-elimination from chlorohydrazonoalkyl-phosphine oxides and -phosphonates in the presence of bases. Michael addition (1,4-addition) of ammonia, aliphatic and aromatic amines and aminoesters to these azo-alkenes gives functionalized α-amino-phosphine oxides and -phosphonates.

Keywords:	α-Amino-phosphine oxides α-Amino-phosphonates 4-Phosphinyl-1,2-diaza-1,3-butadienes 4-Phosphonyl-1,2-diaza-1,3-butadienes Hydrazones Michael addition
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