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Practical application of new catalytic methods: a concise synthesis of a potent PDE IV inhibitor |
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| Authors: | Jennifer Albaneze-Walker Jerry A Murry Arash Soheili Scott Ceglia Shawn A Springfield Charles Bazaral Peter G Dormer David L Hughes |
| Institution: | Process Research, Merck Research Laboratories, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an efficient palladium-catalyzed Suzuki-Miyaura coupling of a chloropyridine-N-oxide. |
| Keywords: | Naphthyridone Pyridine Suzuki-Miyaura coupling Carbonylation N-Oxide |
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