Lannotinidines A-G, new alkaloids from two species of Lycopodium |
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| Authors: | Koichiro Koyama Yusuke Hirasawa Tomohiro Hoshino Norimichi Nakahata |
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| Institution: | a Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
b Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan |
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| Abstract: | Seven new Lycopodium alkaloids, lannotinidines A-G (1-7), have been isolated from the club moss Lycopodium annotinum and L. annotinum var. acrifolium. Stereochemistry of 1-7 was elucidated by combination of NOESY correlations and chemical transformation. Lannotinidines B-E (2-5) elevated NGF mRNA expression. |
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| Keywords: | Alkaloids Lycopodium Lannotinidines A-G NGF biosynthesis |
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