Facile one-pot synthesis of BINOL- and H<sub>8</sub>-BINOL-based aryl phosphites and their use in palladium catalysed asymmetric allylation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Facile one-pot synthesis of BINOL- and H₈-BINOL-based aryl phosphites and their use in palladium catalysed asymmetric allylation

Authors:	Konstantin N. Gavrilov Pavel V. Petrovskii AntonS. Safronov Vadim A. Davankov

Affiliation:	^a Department of Chemistry, Ryazan State Pedagogic University, 46 Svoboda Street, Ryazan 390000, Russia ^b Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Street, 119991 Moscow, Russia

Abstract:	Novel P-monodentate aryl phosphite ligands have been synthesised in one step from (R)-BINOL, (R)-H₈-BINOL and (R)-H₈-3,3′-dibromo-BINOL. With the new aryl phosphites, up to 86% ee was observed in the asymmetric Pd-catalysed amination of 1,3-diphenyl-2-propenyl acetate with sodium diformylamide. In the enantioselective alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate, up to 97% enantioselectivity was achieved.

Keywords:	P-monodentate phosphite ligands Asymmetric Pd-catalysed amination Enantioselective alkylation
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