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Novel cytotoxic kaurane-type diterpenoids from the New Zealand Liverwort Jungermannia species |
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| Authors: | Fumihiro Nagashima Masuo Kondoh Shigeru Takaoka Yoshinori Asakawa |
| Institution: | a Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan b Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan |
| Abstract: | Novel cytotoxic rearranged kaurene- and ent-kaurene-type diterpenoids against HL-60 cells have been isolated from the unidentified New Zealand liverwort Jungermannia species together with previously known ent-kaurane-type diterpenoids. Their structures were determined by extensive NMR techniques, chemical degradation and X-ray crystallographic analysis. |
| Keywords: | Jungermannia Liverwort Kaurane-type diterpenoid Cytotoxic |
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