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| 聚乙二醇-水介质中水溶性膦稳定的钌催化芳香酮的不对称加氢反应 | |
| 引用本文： | 秦瑞香,王金波,熊伟,刘德蓉,冯建,陈华.聚乙二醇-水介质中水溶性膦稳定的钌催化芳香酮的不对称加氢反应[J].催化学报,2011,32(9):1490-1495. |
| 作者姓名： | 秦瑞香 王金波 熊伟 刘德蓉 冯建 陈华 |
| 作者单位： | 1. 重庆科技学院化学化工学院,重庆,401331 2. 重庆科技学院化学化工学院,重庆 401331;四川大学化学学院,绿色化学及技术教育部重点实验室,四川 成都 610064 3. 四川大学化学学院,绿色化学及技术教育部重点实验室,四川 成都 610064 |
| 基金项目： | 重庆市自然科学基金(2010BB8280); 重庆市教委科学技术研究项目(KJ101410)~~ |
| 摘 要： | 在聚乙二醇-400-水介质中,以(1S,2S)-1,2-二苯基乙二胺的磺酸钠盐为手性修饰剂,考察了水溶性三(间-磺酸钠苯基)膦稳定的Ru催化苯乙酮及其衍生物的不对称加氢反应.结果表明,该催化剂体系具有良好的催化活性和对映选择性.在优化反应条件下,苯乙酮转化率和对映选择性分别为100％和84.9％.经正己烷萃取后,催化剂... |
| 关 键 词： | 水溶性膦稳定的钌 芳香酮 不对称加氢 芳香仲醇 聚乙二醇-水 |
Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Achiral Monophosphine TPPTS-Stabilized Ru in PEG-Water |
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| QIN Ruixiang,WANG Jinbo,XIONG Wei,LIU Derong,FENG Jian,CHEN Hua.Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Achiral Monophosphine TPPTS-Stabilized Ru in PEG-Water[J].Chinese Journal of Catalysis,2011,32(9):1490-1495. | |
| Authors: | QIN Ruixiang WANG Jinbo XIONG Wei LIU Derong FENG Jian CHEN Hua |
| Institution: | QIN Ruixiang1,WANG Jinbo1,2,a,XIONG Wei1,LIU Derong1,FENG Jian1,CHEN Hua2,b 1College of Chemistry and Chemical Engineering,Chongqing University of Science and Technology,Chongqing 401331,China 2Key Laboratory of Green Chemistry and Technology of Ministry of Education,College of Chemistry,Sichuan University,Chengdu 610064,Sichuan,China |
| Abstract: | PEG-400 was found to be a green and recyclable reaction medium for asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS (P(m-C6H4SO3Na)3), stabilized ruthenium modified by (1S,2S)-DPENDS (DPENDS: disodium salt of sulfonated (1S,2S)-1,2-diphenyl-1,2-ethylene-diamine). A 84.9% ee was obtained for acetophenone under the optimized conditions. The resulting products can be easily separated from the catalyst by extraction with n-hexane. The catalyst immobilized on PEG-400 not only... |
| Keywords: | TPPTS-stabilized ruthenium aromatic ketone asymmetric hydrogenation aromatic sec-alcohol polyethylene glycol-400-water |
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