Synthesis,copper(II) complexes and catalytic activity of substituted 6-(1,3-oxazolin-2-yl)pyridine-2-carboxylates |
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Authors: | Pavel Drabina Petr Funk Aleš Růžička Jiří Hanusek Miloš Sedlák |
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Institution: | 1.Institute of Organic Chemistry and Technology, Faculty of Chemical Technology,University of Pardubice,Pardubice,Czech Republic;2.Department of General and Inorganic Chemistry, Faculty of Chemical Technology,University of Pardubice,Pardubice,Czech Republic |
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Abstract: | The optically pure 6-(4-alkyl-4,5-dihydro-1,3-oxazol-2-yl)pyridine-2-carboxylates have been prepared from 6-methoxycarbonylpyridine-2-carboxylic
acid by a sequence of three reactions with the overall yield of 40–50%. Some of these compounds form stable complexes with
Cu(II) ions in non-aqueous medium. Their polymeric structure was determined in the solid phase by X-ray diffraction analysis.
The Cu(II) complexes were also used as catalysts for addition reactions of terminal alkynes to imines giving substituted propargylamines
with maximum yield 64% and 37% ee. |
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Keywords: | |
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