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| Synthesis,Crystal Structure and Neuroprotection of Methyl 2-（（4-（2-（2-Methylphenoxy）acetyl）- piperazin-1-yl）-methyl）benzoate① | |
| 引用本文： | 仲琰,王垚,王晶,许逸,李萍,吴斌.Synthesis,Crystal Structure and Neuroprotection of Methyl 2-（（4-（2-（2-Methylphenoxy）acetyl）- piperazin-1-yl）-methyl）benzoate①[J].结构化学,2014,33(7):1096-1101. |
| 作者姓名： | 仲琰 王垚 王晶 许逸 李萍 吴斌 |
| 作者单位： | [1]School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China; [2]School of Pharmacy, Nanjing Medical University, Nanjing 211166, China; [3]School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China |
| 基金项目： | Supported by the National Natural Science Foundation of China(No.81371451);the Natural Science Foundation of Jiangsu Province(No.BK20131390) |
| 摘 要： | A new phenoxyacetamide derivative, methyl 2-((4-(2-(2-methylphenoxy)acetyl)piperazin-1-yl)methyl)benzoate(C22H26N2O4, Mr = 382.45), has been synthesized and characterized by 1H NMR, 13 C NMR, H RMS and single-crystal X-ray diffraction. The crystal is of monoclinic system, space group P21/c with a = 11.145(2), b = 13.667(3), c = 13.998(3)A, β = 112.01(3)o, V = 1976.8(7)A3, Z = 4, Dc = 1.285 g/cm3, F(000) = 816, μ = 0.089 mm-1, MoKα radiation(λ = 0.71073 A), the final R = 0.0602 and wR = 0.1533 for 2343 observed reflections with I 2σ(I). Intramolecular C–H···O interactions as well as intermolecular C–H···O hydrogen bonds help to stabilize the crystal structure. The preliminary bioassay results show that the title compound exhibits potent neuroprotective activity. |
| 关 键 词： | 甲基苯氧基 苯甲酸甲酯 晶体结构 神经保护 乙酰基 合成 单晶X射线衍射 酰胺衍生物 |
Synthesis,Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-piperazin-1-yl)-methyl)benzoate |
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| ZHONG Yan , WANG Yao , WANG Jing , XU Yi , LI Ping , WU Bin.Synthesis,Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-piperazin-1-yl)-methyl)benzoate[J].Chinese Journal of Structural Chemistry,2014,33(7):1096-1101. | |
| Authors: | ZHONG Yan WANG Yao WANG Jing XU Yi LI Ping WU Bin |
| Institution: | 1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China 2. School of Pharmacy, Nanjing Medical University, Nanjing 211166, China 3. School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China |
| Abstract: | phenoxyacetamide, crystal structure, synthesis, neuroprotection |
| Keywords: | phenoxyacetamide crystal structure synthesis neuroprotection |
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