Formal anti‐Carbopalladation Reactions of Non‐Activated Alkynes: Requirements,Mechanistic Insights,and Applications |
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| Authors: | M.Sc. Martin Pawliczek Dr. Tobias F. Schneider Dr. Christian Maaß Prof. Dr. Dietmar Stalke Prof. Dr. Daniel B. Werz |
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| Affiliation: | 1. Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen (Germany);2. Institut für Organische Chemie, Technische Universit?t Braunschweig, Hagenring 30, 38106 Braunschweig (Germany) http://www.werzlab.de;3. Institut für Anorganische Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstrasse 4, 37077 G?ttingen (Germany) |
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| Abstract: | ![]()
Formal anti‐carbopalladation reactions of C? C triple bonds are uncommon, but highly useful transformations. Alkynes can be designed to give anti‐carbopalladation products. Prerequisite is the exclusion of other reaction pathways to provoke the cis–trans isomerization of the syn‐carbopalladation intermediate. Detailed mechanistic studies of this crucial step by experimental and computational means were performed. Application of an intramolecular version for the synthesis of oligocyclic compounds and substituted dibenzofurans is also described. |
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| Keywords: | anti‐carbopalladation domino reaction palladium reaction mechanisms |
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