Synergistic Interplay of a Non‐Heme Iron Catalyst and Amino Acid Coligands in H2O2 Activation for Asymmetric Epoxidation of α‐Alkyl‐Substituted Styrenes |
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| Authors: | Olaf Cussó Dr Xavi Ribas Dr Julio Lloret‐Fillol Dr Miquel Costas |
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| Institution: | Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus de Montilivi, 17071 Girona, Catalonia (Spain) |
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| Abstract: | Highly enantioselective epoxidation of α‐substituted styrenes with aqueous H2O2 is described by using a chiral iron complex as the catalyst and N‐protected amino acids (AAs) as coligands. The amino acids synergistically cooperate with the iron center in promoting an efficient activation of H2O2 to catalyze epoxidation of this challenging class of substrates with good yields and stereoselectivities (up to 97 % ee) in short reaction times. |
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| Keywords: | amino acids asymmetric catalysis bioinspired catalysis epoxidation non‐heme iron complexes |
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