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Condensed‐Phase,Halogen‐Bonded CF3I and C2F5I Adducts for Perfluoroalkylation Reactions |
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| Authors: | Dr. Filippo Sladojevich Dr. Eric McNeill Jonas Börgel Dr. Shao‐Liang Zheng Prof. Dr. Tobias Ritter |
| Affiliation: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138 (USA) http://rittergroup.org |
| Abstract: | A family of practical, liquid trifluoromethylation and pentafluoroethylation reagents is described. We show how halogen bonding can be used to obtain easily handled liquid reagents from gaseous CF3I and CF3CF2I. The synthetic utility of the new reagents is exemplified by a novel direct arene trifluoromethylation reaction as well as adaptations of other perfluoroalkylation reactions. |
| Keywords: | arenes C H functionalization halogen bonding pentafluoroethylation trifluoromethylation |