Concise synthesis of a pentasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O102 |
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Authors: | Abhijit Sau Debashis Dhara Anup Kumar Misra |
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Institution: | Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India |
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Abstract: | An efficient synthetic strategy has been developed for the synthesis of a pentasaccharide repeating unit of the O-antigen of Escherichia coli O102 strain. The target pentasaccharide 1 has been synthesized using a 2+3] block glycosylation strategy. All glycosylation steps are highly stereoselective and high yielding. Concept of armed-disarmed and orthogonal glycosylation strategies has been applied during the synthesis. The target compound has been synthesized using the minimum number of steps. |
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