Enantiodivergence in the reduction of α-methyl and α-halomethyl enones by microorganisms |
| |
Authors: | Bruno RS de Paula Dávila S Zampieri J Augusto R Rodrigues Paulo JS Moran |
| |
Institution: | Institute of Chemistry, University of Campinas, 13084-971 Campinas, SP, Brazil |
| |
Abstract: | Enones (Z)-3-methyl-(Z)-3-chloromethyl- and (Z)-3-bromomethyl-4-R-3-buten-2-one (R = n-pentyl, phenyl, 2′- and 4′-chlorophenyl, 3′- and 4′-nitrophenyl, 4′-methoxyphenyl) were synthesized and subjected to reduction by the microorganisms Saccharomyces cerevisiae andGeotrichum candidum. Whereas the bioreduction of 3-methy-4-R-3-buten-2-ones afforded the corresponding (S)-4-R-3-methybutan-2-ones, the bioreduction of 3-chloromethyl- and 3-bromomethyl-4-R-3-buten-2-ones afforded the corresponding (R)-4-R-3-methybutan-2-ones. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|