Catalytic enantioselective synthesis of optically active α-hydroxyl-β,γ-unsaturated acid esters as novel side chains of cerebrosides |
| |
| Authors: | Lei Wang Ruiquan Liu Cong Lv Junjun Ou Feng Liu Shangzhong Liu Min Wang Jiangchun Zhong |
| |
| Institution: | Department of Applied Chemistry, China Agricultural University, 2 West Yuanmingyuan Road, Beijing 100193, PR China |
| |
| Abstract: | Six optically active α-hydroxyl-β,γ-unsaturated acid esters 1a to 1f were synthesised, and they are significant moieties of the cerebrosides. The chiral intermediate alkynol 4 prepared by catalytic asymmetric addition had 99% ee, and which was converted into the target compounds 1a to 1f with high enantiomeric purity. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
