A flexible enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A using asymmetric transfer hydrogenation/tandem Grubbs cross-metathesis/oxy-Michael reaction as key steps |
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| Authors: | Gullapalli Kumaraswamy Dasa Rambabu |
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| Institution: | Organic & Biomolecular Chemistry Division, CSIR—Indian Institute of Chemical Technology, Hyderabad 500 607, India |
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| Abstract: | An efficient enantioselective synthesis of (+)-centrolobine and 5-epi-diospongin-A was achieved by the use of asymmetric transfer hydrogenation (ATH)/tandem Grubbs cross-metathesis/oxy-Michael reaction. Furthermore, this strategy allows for diastereodivergent access to every representative member of the family. |
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