| 过渡金属催化下N-取代苯基-苯并噻噁唑酮-3-甲酰胺的合成及其生物活性 |
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| 引用本文： | 翁建全,刘幸海,张国富,谭成侠,丁成荣,欧晓明.过渡金属催化下N-取代苯基-苯并噻噁唑酮-3-甲酰胺的合成及其生物活性[J].有机化学,2011,31(3). |
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| 作者姓名： | 翁建全 刘幸海 张国富 谭成侠 丁成荣 欧晓明 |
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| 作者单位： | 1. 浙江工业大学化学工程与材料学院,杭州,310032
2. 国家南方农药创制中心湖南基地,长沙,410007 |
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| 基金项目： | 国家自然科学基金，浙江省自然科学基金 |
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| 摘 要： | 为了寻找新的含苯并噻(噁)唑稠杂环农药先导化合物,利用(6-氯)-苯并噻(噁)唑酮与取代苯基异氰酸酯发生偶合反应,合成了15个N-取代苯基-苯并噻(噁)唑酮-3-甲酰胺化合物3,并利用1H NMR,IR,MS及元素分析对其结构进行了表征.初步生物活性试验结果表明,在试验浓度下部分目标化合物具有一定的杀菌和杀虫活性.考察了部分过渡金属催化剂对该偶合反应的催化效果,结果表明在钯催化、温和条件下即可较高产率得到产物.
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| 关 键 词： | 过渡金属催化 苯并噻(噁)唑酮 取代苯基异氰酸酯 合成 生物活性 |
Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone |
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| Weng Jianquan,Liu Xinghai,Zhang Guofu,Tan Chengxia,Ding Chengrong,Ou Xiaoming.Transition-Metal-Catalyzed Synthesis and Biological Activities of N-Arylaminocarbonyl-2-benzothiazolinone/benzoxazolone[J].Chinese Journal of Organic Chemistry,2011,31(3). |
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| Authors: | Weng Jianquan Liu Xinghai Zhang Guofu Tan Chengxia Ding Chengrong Ou Xiaoming |
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| Institution: | Weng,Jianquan,a Liu,Xinghaia Zhang,Guofua Tan,Chengxiaa Ding,Chengronga Ou,Xiaomingb(a College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou 310032)(b Hunan Branch of National Southern Pesticide Research Centre,Changsha 410007) |
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| Abstract: | In order to find new benzothiazole/benzoxazole lead compounds,15 N-arylaminocarbonyl-2-benzothiazolinone/benzoxazolone derivatives were synthesized from a coupling reaction of 2-benzothia-zolinone/benzoxazolone and aryl isocyanates catalyzed by transition-metal.Their structures were confirmed by 1H NMR,IR,MS techniques and elemental analysis.The preliminary bioassay showed that some of them exhibited certain fungicidal and insecticidal activities.The influence of some transition-metal catalyst on the coupli... |
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| Keywords: | transition-metal-catalyzed 2-benzothiazolinone/benzoxazolone substituted phenyl isocyanate synthesis biological activity |
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