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Progress towards artificial hydrolases: synthesis and binding properties of a water-soluble cyclophane host with a phenol cap
Affiliation:1. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, United States;2. Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, United States;3. The Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego, La Jolla, CA 92093, United States;4. The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark;1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, PR China;2. WPI-MANA, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan;3. Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan;1. Afton Chemical Ltd., Bracknell, Berkshire RG12 2UW, UK;2. Department of Mechanical Engineering and Aeronautics, City, University of London, Northampton Square, EC1V 0HB London, UK;3. Afton Chemical Corp, Richmond, VA 23219, USA;4. Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
Abstract:
The synthesis of the functionalized macrobicyclic host1 on the way to the water-soluble artificial esterase 2 is presented. A phenolic nucleophile is properly oriented atop the binding cavity of1 which forms strong complexes with aromatic guests in aqueous solutions.
Keywords:
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