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Trityloxyethylamino group for the protection of phosphoryl group in oligonucleotide synthesis |
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| Affiliation: | 1. Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China;2. Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau;1. Department of Chemistry and Applied Bioscience, ETH Zurich, Zurich, Switzerland;2. YPSO-FACTO, 10 Viaduc Kennedy, 54000 Nancy, France |
| Abstract: |  Trityloxyethylamino group was used for the protection of 5′-phosphoryl group of deoxyribonucleoside. This group is not only protecting group of phosphate also the intermediate for the synthesis of d-ppA and d-pppA. |
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