Reactions with 5-aminopyrazoles. I. Synthesis of halogen-containing fused pyrazoles |
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| Authors: | Hamdy A. Hammouda Ahmed A. El-Barbary Mohie A. F. Sharaf |
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| Affiliation: | Chemistry Department, Faculty of Science, Cairo University, Giza and Tanta University, Tanta, Egypt |
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| Abstract: | ![]()
5-Amino-3-phenylpyrazole (I) and 5-amino-4-bromo-3-phenylpyrazole (II) reacted with ethyl acetoacetate and acetylacetone to give various pyrazolo[1,5-a]pyrimidines IV-VI and with benzoins to give different fused pyrazoles, namely, imidazo[1,2-b]pyrazoles IX, pyrrolo[2,3-c]pyrazoles X and pyrazolo[4,3-b][1,4]oxazines XII. Diazotized II was coupled with active methylene-containing nitriles to afford pyrazolo[5,1-c]-as-triazines XIV. |
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