Synthesis of 3H[1,2]diazepino[5,6-b]indole and 3H[1,2]diazepino[4,5-b]indole derivatives |
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| Authors: | A Monge J A Palop T Goñi A Martinez E Fernández-Alvarez |
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| Institution: | 1. Facultad de Farmacia, Departamento de Química Orgánica y Farmaceutica, Universidad de Navarra, Pamplona, Spain;2. Centro Nacional de Química Orgánica, C/Juan de la Cierva, No. 3, Madrid-6, Spain |
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| Abstract: | The synthesis of two new derivatives of 3H1,2]diazepino5,6-b]indole, 5 and 11 , and one new derivative of 3H1,2]diazepino4,5-b]indole, 16 , are described. Compound 5 was obtained by the reaction of methyl 2-(3-methoxycarbonyl-1-methylindole)acetate 2 , with hydrazine. Compound 11 was obtained in two ways from ethyl 2-(1-methylindole)acetate ( 8 ) by formylation and reaction with hydrazine. Compound 16 was obtained treating 3-(2-ethoxycarbonylindole)acetonitrile ( 14 ) with hydrazine. |
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