| DNA与两性表面活性剂相互作用研究 |
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| 引用本文： | 孙彦庆,张剑,张高勇,王红霞.DNA与两性表面活性剂相互作用研究[J].化学进展,2006,18(11):1440-1445. |
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| 作者姓名： | 孙彦庆 张剑 张高勇 王红霞 |
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| 作者单位： | 1. 中国日用化学工业研究院表面活性剂国家工程研究中心,太原,030001
2. 太原理工大学煤科学与技术教育部和山西省重点实验室,太原,030032 |
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| 摘 要： | 本文综述了DNA与两性表面活性剂相互作用的研究进展，主要介绍了利用荧光显微镜、动静态光散射、相图及浊度等方法对DNA与两性表面活性剂相互作用的观察与形成复合物的表征。由于两性表面活性剂所具有的独特性质，可以实现在特定pH范围通过静电作用诱导DNA构象发生线圈状向小球状的不连续转变，并可通过调节溶液pH值、离子强度等实现对DNA-两性表面活性剂复合物的稳定性的调控。DNA与两性表面活性剂相互作用形成的复合物在非病毒基因载体研究方面具有潜在的应用价值。
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| 关 键 词： | DNA 两性表面活性剂 相互作用 基因载体 |
| 文章编号： | 1005-281X（2006）11-1440-06 |
| 收稿时间： | 2005-12 |
| 修稿时间： | 2006-02 |
The Interaction between DNA and Amphoteric Surfactants |
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| Sun Yanqing,Zhang Jian,Zhang Gaoyong,Wang Hongxia.The Interaction between DNA and Amphoteric Surfactants[J].Progress in Chemistry,2006,18(11):1440-1445. |
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| Authors: | Sun Yanqing Zhang Jian Zhang Gaoyong Wang Hongxia |
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| Institution: | 1. State Center for Surfactant Research and Engineering, China Research Institute of Daily Chemical Industry, Taiyuan 030001, China; 2. Key Laboratory of Coal Science and Technology, Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030032, China |
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| Abstract: | The research progress of interaction between DNA and amphoteric surfactant is reviewed. Relevant studying methods of interaction-observering and complex-charactering, such as fluorescent microscopic technology, light scattering, phase diagram and turbidimetric titration are expatiated. Owing to the characteristic of amphoteric surfactant, in specific range of pH it could induce discrete conformations] transition of DNA from unfolded coil to compacted globule by electrostatic attraction. Interaction between DNA and amphoteric surfactant is controlled by pH and ion strength. The DNA-amphoteric surfactant complexes have potential application as gene vectors. |
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| Keywords: | DNA |
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