Petasis three-component coupling reactions of hydrazides for the synthesis of oxadiazolones and oxazolidinones |
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| Authors: | Le Quement Sebastian T Flagstad Thomas Mikkelsen Remi J T Hansen Mette R Givskov Michael C Nielsen Thomas E |
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| Affiliation: | Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. |
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| Abstract: | An application of readily available hydrazides in the Petasis 3-component coupling reaction is presented. An investigation of the substrate scope was performed to establish a general, synthetically useful protocol for the formation of hydrazido alcohols, which were selectively converted to oxazolidinone and oxadiazolone ring systems through triphosgene-mediated cyclization reactions. |
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