Synthesis of acyl pyrroles via palladium-catalyzed carbonylative amination of aryl and alkenyl iodides |
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| Authors: | Ho Stephanie Bondarenko Ganna Rosa David Dragisic Bojan Orellana Arturo |
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| Institution: | Department of Chemistry, York University, 440 Chemistry Building 4700 Keele Street, Toronto, ON, Canada M3J 1P3. |
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| Abstract: | A palladium-catalyzed synthesis of acyl pyrroles from aryl and alkenyl iodides is reported. This carbonylative amination requires only atmospheric (balloon) pressure of carbon monoxide and proceeds with Pd(PPh(3))(4) and Pd-NHC catalysts. Aryl and heteroaryl iodides give the corresponding acyl pyrroles in good to excellent yields, while alkenyl iodides provide the corresponding acyl pyrroles in low to moderate yields. |
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