Chiral ligand-exchange chromatography on an RP HPLC column coated with a new chiral selector derived froml-spinacine |
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| Authors: | M Remelli D Trombin C Conato |
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| Institution: | (1) Department of Chemistry, University of Ferrara, via L. Borsari 46, 44100 Ferrara, Italy |
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| Abstract: | Summary A commercial reversed-phase (RP) C18 HPLC column has been dynamically coated with the chiral selectorN
τ-n-decyl-l-spinacine and then loaded with copper(II) ions. Several racemic mixtures of underivatized amino acids and oligopeptides were
resolved on the column by chiral ligand-exchange chromatography. The most important experimental conditions affecting column
efficiency, retention, and selectivity (temperature and mobile phase flow rate and composition) were extensively investigated. |
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| Keywords: | Column liquid chromatography Chiral separations Ligand exchange N τ l-spinacine" target="_blank">-n-decyl-l-spinacine Amino acids |
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