Solid-supported synthesis of a peptide beta-turn mimetic |
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| Authors: | Golebiowski A Klopfenstein S R Shao X Chen J J Colson A O Grieb A L Russell A F |
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| Affiliation: | Procter & Gamble Pharmaceuticals, Combinatorial Chemistry Group, Health Care Research Center, Mason, Ohio 45040-8006, USA. golebiowskia@pg.com |
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| Abstract: | ![]()
[structure: see text]The solid-supported synthesis of a bicyclic diketopiperazine, a potential peptide beta-turn mimetic, is described. The Ugi reaction between the resin ester of alpha-N-Boc-diaminopropionic acid (an amine input), alpha-bromo acid, aldehyde, and isocyanide is the key step in the proposed protocol. |
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