From galactose to highly functionalized seven- and eight-membered carbocyclic rings by ring-closing metathesis |
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Authors: | Hanna I Ricard L |
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Affiliation: | Laboratoire de Synthèse Organique associé au CNRS, Ecole Polytechnique, Palaiseau, France. hanna@poly.polytechnique.fr |
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Abstract: | [reaction: see text]A short synthesis of highly functionalized seven- and eight-membered carbocyclic rings from galactose derivatives has been achieved. The key steps are a zinc-mediated reductive ring opening of 6-iodogalactopyranoses and a subsequent ring-closing olefin metathesis using Grubbs' ruthenium catalyst. |
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