氟烷基三甲基硅化合物的合成和反应研究

羰基化合物的氟烷基化反应是把含氟基团引入有机分子中去的一个重要手段。文献报道的主要是通过氟烷基金属试剂来进行此反应。但氟烷基金属试剂不太稳定,容易分解。这就给它们的应用带来了许多不便。我们发现,氟烷基三甲基硅化合物(1)作为氟烷基阴离子前体,在比较温和的条件下,便可使醛发生氟烷基化反应。首先,参照文献方法,通过氟烷基格氏试剂与三甲基氯硅烷反应,方便地制得了两个新的氟烷基三甲基硅化合物 R_F-SiMe_3(1)。

The Synthesis and Reactions of Polyfluoroalkyltrimethylsilane

The polyfluoroalkyltrimethylsilane compounds.(1)were prepared.They can be usedto introduce the polyfluoroalkyll group into carbonyl compounds,giving the correspoundingalchols.The Carbon-Silicon bond was cleaved by fluoride or bases to produce polyfluoroalkylanion which abstracted hydrogen to give hydroperfluoroalkane(2)or reacted with aldehydesto give polyfluoroalkyl carbinols(3).The alkyl exchange reaction between polytluoroalkylsi-lanes with organolithium compounds have also been carried out.