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Studies on the electrochemistry of rutin and its interaction with bovine serum albumin using a glassy carbon electrode modified with carbon-coated nickel nanoparticles |
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| Authors: | Liansheng Duan Lijun Yang Huayu Xiong Xiuhua Zhang Shengfu Wang |
| Institution: | 1. Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, People’s Republic of China 2. Department of Chemistry and Life Science, Hubei University of Education, Wuhan, 430205, People’s Republic of China |
| Abstract: | We report on a glassy carbon electrode modified with carbon-coated nickel nanoparticles (C-Ni/GCE) that can be used to study the electrochemical properties of rutin and its interaction with bovine serum albumin (BSA) via cyclic voltammetry and differential pulse voltammetry. The effects of pH value, accumulation potential, accumulation time and reaction time were optimized. A pair of reversible peaks is found in the potential range of 0 to around 0.6 V at pH?5.0. Two linear response ranges (with different slopes) are found, one in the 2 to 210 nM concentration range, the other between 0.21 and 1.72 μM. The detection limit is as low as 0.6 nM. On addition of BSA to the rutin solution, a decrease of the current is observed that is proportional to the concentration of BSA. The binding constant and stoichiometric ratio were calculated. 1. Preparation of carbon-coated nickel nanoparticles modified glassy carbon electrode (C-Ni/GCE). 2. C-Ni/GCE improves the electrochemical redox of rutin. 3. The prepared electrode determines rutin with high sensitivity and selectivity. 4. The developed method can determine rutin and its interaction with bovine serum albumin. |
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