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Three antibacterial naphthoquinone analogues from cultured mycobiont of lichen Astrothelium sp. |
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| Authors: | Li Yan Sun Zhen Liang Liu Tao Zhang Shu Bin Niu Zun Tian Zhao |
| Institution: | a College of Pharmacology, Taishan Medical University, Taian 271016, China;b College of Life Sciences, Shandong Normal University, Jinan 250014, China;c College of Chemistry and Chemical Engineering, Taishan Medical University, Taian 271016, China;d Key Lab of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
| Abstract: | A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 were isolated from cultured mycobiont of Astrothelium sp. The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures. Compound 1 displayed significant antibacterial activity against Bacillus subtilis (ATCC 6633), and showed modest antibacterial activity against Staphylococcus aureus col (MRSA) (CGMCC 1.2465). While compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E (CGMCC 1.2135) and Staphylococcus aureus col (MRSA) (CGMCC 1.2465). |
| Keywords: | Astrothelium sp Lichen Mycobiont 7-Hydroxyl-8-methoxyltrypethelone |
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