Camps reaction for the synthesis of 3-RS-4-arylquinolin-2-ones |
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| Authors: | Prezent M. A. Dorokhov V. A. |
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| Affiliation: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
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| Abstract: | ![]()
The replacement of the chlorine atom in 2-(chloroacetamido)benzophenones on treatment with RSH (R = Alk, Ar, Hetaryl) in the presence of MeONa is accompanied by intramolecular cyclization following the Camps reaction pattern to give 3-RS-4-arylquinolin-2-ones. Cleavage of 4-aryl-3-(benzoxazol-2-ylthio)quinolin-2-ones by morpholine has resulted in the corresponding 4-aryl-3-mercaptoquinolin-2-ones. |
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| Keywords: | Camps reaction 2-(chloroacetamido)benzophenones thiols 3-aryl(hetaryl)thioquinolin-2-ones 4-aryl-3-mercaptoquinolin-2-ones |
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