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Synthesis and characterization of HPMA copolymer-5-FU conjugates |
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| Authors: | Fang Yuan Fu Chen Qing Yu Xiang Xuan Qin Zhi Rong Zhang Yuan Huang |
| Institution: | Key Laboratory of Drug Targeting of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
| Abstract: | N-(2-Hydroxypropyl)methacrylamide copolymer-5-fluorouracil (PHPMA-FU)conjugates were synthesized by a novel and simplified synthetic mute,and characterized by UV,FTIR and HPLC analyses.The conjugated content of 5-fluorouracil (5-FU)was 3.41 ± 0.07 wt%.The stabilities of PHPMA-FU conjugates under different conditions were studied.The results showed that HPMA copolymer was a potential carrier for tumor-targeting delivery of 5-FU. |
| Keywords: | HPMA copolymer 5-Fluorouracil Conjugates Characterization Stability |
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