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Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives |
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| Authors: | A Ghanem H Y Aboul-Enein F Lacrampe S Grass Z Jiang P Müller |
| Institution: | (1) Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland;(2) Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia;(3) Institute of Organic Chemistry, University of Tübingen, Auf der Morgenstelle 18, 72076 Tübingen, Germany |
| Abstract: | Chirasil- -Dex was used as chiral stationary phase for the enantioselective gas chromatographic analysis of several new chiral cyclopropane derivatives. The GC method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the inter- and intra-molecular cyclopropanation reactions and avoids time-consuming work-up procedures. |
| Keywords: | Gas chromatography Enantiomeric excess Chirasil- |
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