Highly sensitive method for the determination of a new anthracycline: Pirarubicin |
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| Authors: | D. Marchiset-Leca F. R. Leca |
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| Affiliation: | (1) Laboratoire de Pharmacocinétique, CHD de Castelluccio, B.P. 85, 20176 Ajaccio, France;(2) Faculté de Pharmacie, Laboratoire de Pharmacocinétique, 27 Bd Jean Moulin, 13385 Marseille, France |
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| Abstract: | Summary A new and highly sensitive HPLC method for the simultaneous determination of pirarubicine (THP-doxorubicin) and its metabolites, adriamycin and adriamycinol, in human plasma, is described. Samples were treated by liquid-liquid extraction, the organic phase removed and the residue dissolved in methanol. Separation was on a Lichrocart Supersher RP 8 column, (250×4 mm) 4  m, with a mobile phase of acetonitrile/methanol/formate-buffer. |
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| Keywords: | Column liquid chromatography Pirarubicin and metabolites Anthracyclines |
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