The preparation of dopaminergic agonist [5,8-3H] (+/-) 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

The rigid dopamine analogue (+/-) 6,7-ADTN was originally synthesized to probe the geometrical constraints of the dopamine receptor family and ³H] (+/-) 6,7-ADTN was required for receptor binding assay. The radioligands was prepared by means of catalytic tritium dehalogenation of a suitable dibromo precursor and characterized by HPLC and tritium NMR. It has proven very useful as a tool to study dopaminergic receptors.