无过渡金属条件下喹啉C5位碳-氢键官能化反应

喹啉是一类重要的杂环化合物,喹啉类化合物的合成方法研究备受关注。通过喹啉的碳-氢键直接官能化反应制备取代喹啉类衍生物是一种简便而有效的方法。然而,喹啉的C5位选择性碳-氢键官能化反应仍然存在挑战,目前大多在过渡金属催化下实现,无过渡金属条件下的反应亟待开发。本文按成键类型(碳-卤键、碳-氮键、碳-氧键、碳-硫键和碳-碳键)分类综述了近年来在无过渡金属条件下喹啉C5位碳-氢键官能化反应的研究进展,并对该领域的研究现状及所存在的问题进行了总结。

The C5 C-H Bond Functionalization of Quinolines under Transition-Metal Free Conditions

Quinoline is an important class of heterocyclic compounds, and research on the synthesis of quinoline compounds has attracted much attention. It is simple and efficient to prepare substituted quinolines though direct C-H bond functionalization of quinolines. However, the C5-selective C-H bond functionalization of quinolines is still a challenge. Most current methods are achieved by transition metal catalysis. The reactions under transition metal-free conditions are desired. In this paper, the recent advance of C5 C-H bond functionalization of quinolines under transition-metal free conditions is reviewed according to the types of bond (C-X, C-N, C-S, C-O and C-C) formation. And the research status and current problems in this field are also summarized.