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Synthesis of Cyclooctatetraenes through a Palladium‐Catalyzed Cascade Reaction |
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| Authors: | Sarah Blouin Prof. Vincent Gandon Dr. Gaëlle Blond Dr. Jean Suffert |
| Affiliation: | 1. Université de Strasbourg, Faculté de Pharmacie, UMR 7200 CNRS/UDS, Illkirch-Graffenstaden, France;2. ICMMO, CNRS UMR 8182, Univ. Paris-Sud, Université Paris-Saclay, Orsay cedex, France;3. ICSN, CNRS UPR 2301, Univ. Paris-Sud, Université Paris-Saclay, Gif-sur-Yvette, France |
| Abstract: | Reported is a cascade reaction leading to fully substituted cyclooctatetraenes. This unexpected transformation likely proceeds through a unique 8π electrocyclization reaction of a ene triyne. DFT computations provide the mechanistic basis of this surprizing reaction. |
| Keywords: | alkenes density functional calculations electrocyclizations palladium reaction mechanisms |