An efficient approach for monofluorination via aqueous fluorolactonization reaction of 2,3-allenoic acids with selectfluor |
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| Authors: | Zhou Chao Ma Zhichao Gu Zhenhua Fu Chunling Ma Shengming |
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| Affiliation: | Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, PR China. |
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| Abstract: | ![]()
We have developed a convenient method for the efficient monofluorination via the electrophilic fluorocyclization reaction of 2,3-allenoic acids with Selectfluor in MeCN in the presence of 10 equiv of H2O or even in pure water to afford beta-fluorobutenolides in moderate to high yields. |
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